Friedrich Loeffler Institute, Germany

The Friedrich Loeffler Institute (FLI) is the national research center for animal health in Germany. The institute was founded in 1910 and named 1952 according to its founder Friedrich Loeffler. The FLI is situated on the Isle of Riems in the Baltic Sea near the city of Greifswald. Main research areas are animal viral diseases, molecular biology, virus diagnosis, immunology and epidemiology. As part of the current extension the Riems Institute completed Biosafety level 4 (BSL-4) laboratory facilities, which enable research activities on the most dangerous of viruses like Congo Crimean hemorrhagic fever virus, nipahvirus or hendra virus.


  • Teknisk service og vedlikehold
  • Prosjektgjennomføring
  • Rådgivning


  • Elektro
  • Sikkerhet
  • Ventilasjon og klimaanlegg


  • Offentlig sektor
  • Offentlige helsetjenester
  • Eiendomsinvestorer og utviklere


  • Laboratorium/forskning


Installation of HVAC and fire protection systems for BSL-3/4 laboratories that work in pressurized space.
  • HVAC systems for BSL-3/4 laboratories
  • Gas extinguishing systems in pressurized spaces


Caverion installed high-end clean room HVAC system for the facility.


Requirements of HVAC systems in BSL-4 laboratories:

  • Securing the necessary negative pressure and the pressure cascade in the containment
  • HEPA filtering of supply and exhaust air
  • HVAC system installed by Caverion ensures the primary containment and thus contributes significantly to the bio-safety in the laboratory

Requirements of extinguishing systems in BSL-3/4 laboratories:

  • Prevent disruption of negative pressure and the pressure cascade in the containment - Avoid damage to the containment
  • Avoid smoke and fire

Caverion developed a solution suitable for the sensitive area of BSL-4 laboratory at the own R&D center and installed extinguishing systems with Halon substitutes. These types of extinguishers were used in the Riems Institute project due to minimizing of the adverse effects on the laboratory operation and the negative pressure control.


2008 – 2011


Facts about the building

  • New building one of the biggest biosafety laboratories level 3 and 4 worldwide (veterinary)
  • 89 laboratories and 163 animal stables in different biosafety classes

Technical Facts

  • 53 special air handling units with 1.2 million m³/h
  • 1,500 air flow controllers
  • 20,000 m² air lines stainless steel
  • 20,000 m² air lines steel galvanized
  • air tightness class C and D / DIN EN 1507
  • Pressure fixed to 2,000 Pa, tested up to 3,000 Pa
  • 12,000 pieces built-in units / Penetrations of containments
  • 450 special HEPA-filter
  • Special cleaning and measuring equipment
  • Laboratory tests regarding pressure maintainance with Novec 1230 


Facts about Caverion's solutions

  • Ventilation and air conditioning as well as complete electric installations
  • Ventilation system with highest possible pressure stage
  • Contract value approx. 50 million €



Contract value approx.